Manufacturing Services

OUR Capabilities and Competencies

  • DEA Licensed for schedule II-V substances including schedule III-V pallet positions and schedule II pallet positions in DEA inspected vault.
  • Phase I, II, and III clinical supply manufacturing
  • Commercial scale manufacturing
  • High potency suite with glove-box accessibility
  • Dosage form capabilities
    • Powder blending
    • Roller compaction
    • Granulation & fluid bed drying
    • Tableting
    • Aqueous film coating
    • Powder and granule filled hard gelatin capsules
    • Over-encapsulation
    • Liquid fill capsules & banding
    • Creams & gels
  • Warehouse and Distribution including 5°C refrigerated pallet positions
Approach

How We work

PMRS is a full-service contract manufacturer of pharmaceutical products. We handle everything from clinical supply and commercial scale manufacturing to warehousing and distribution. We possess both Solid and Semi-Solid/Liquid Manufacturing equipment, including Twin Screw Extruders.

PMRS Will:

  • Develop and manufacture your product from discovery through commercialization.
  • Scale from small test batches to commercial production efficiently and cost-effectively.
  • Handle all aspects of the process from clinical supply and commercial scale manufacturing to warehousing and distribution.
  • Utilize the latest manufacturing equipment and specialized personnel to provide the highest quality products.
  • Work with you to develop new technologies tailored to your product.
  • Provide expert solutions for the smallest virtual companies as well as the largest pharmaceutical companies in the world.

Our Manufacturing Equipment

Solid Dosage Manufacturing
  • Twin Screw Extrusion
  • Roller Compaction (1kg/hr, 40 kg/hr)
  • Fluid Bed Granulators/Dryers (4L to 420L)
  • High Shear Granulators (10L to 600L)
  • Rotary Mills
  • Comminuting Mills
  • Oscillating Mills
  • Bin Blenders (10L to 1400L Bins)
  • High Speed Rotary Tablet Presses with Interchangeable Turret (24-Station and 36-Station)
  • B Tooling & D Tooling
  • Tablet Film Coaters (15″ to 48″ Pans)
  • Automatic Capsule Filling Machines with powder and pellet capabilities
  • Semi-Automatic Capsule Filling (tablet over-encapsulation)
  • Manual Capsule Filling
  • Glove Box Isolators for high potency compounds (PB-ECL Category 4)
  • 2-Sided Tablet Printing
  • Metal Detection
  • Tablet Dedusting with Integrated Metal Detection
  • Capsule Polishing
  • High Speed Checkweighing
  • Tablet/Capsule Belt Inspection
  • Clinical-scale Tablet/Capsule Counting and Bottling
  • HEPA Filtered Dust Collection
Semi-Solid/Liquid Manufacturing
  • Automatic Hard Capsule Liquid Filling
  • Automatic Hard Capsule Sealing
  • Tube Filling and Sealing
  • Heated Jacketed Kettle with Counter-Rotating Mixers and Homogenizer (10L to 750L)
  • Jacketed Phase Vessel with Propeller Mixer (380L)
  • Planetary Mixing
  • Metal Detection
In-Process Control
  • Particle Flow Testing
  • Particle Size Analysis
  • Variable Temperature Moisture Analysis
  • System Balances- Top-loading and Analytical Platform Scales
  • Automatic Tablet Testing
  • Disintegration Testing
  • Friability Testing
  • Tap Density Testing
  • pH Monitoring

Process Analytical Technology (PAT)

PMRS Inc. strives for improving pharmaceutical compounding through Process Analytical Technology (PAT). PAT offers many advantages over traditional pharmaceutical manufacturing processes; it has been defined by a mechanism to design, analyze, and control pharmaceutical manufacturing processes through the measurement of Critical Process Parameters during the manufacturing process. The PAT platforms at PMRS Inc. make continuous process and real-time release a reality.

One current application of PAT is the verification of blend and content uniformity through Near-Infrared mass spectrometry systems (NIR). PMRS has validated and implemented Prozess Technologie NIR Systems to monitor blend and extrusion content uniformity in real-time. These systems support, and will eventually replace, blend uniformity (BU) and content uniformity (CU) testing that generally occurs after the completion of a batch or campaign. This immediate knowledge reduces batch risks and provides a higher quality product due to 100% testing. Performing this testing during the batch and not in the analytical lab, after completion of manufacturing, allows for shorter release times and gets your product into the hands of the patient faster.

Near-Infrared mass spectrometry systems also permit material identification testing on incoming raw materials. NIR has several advantages over traditional raw materials testing including faster sample times, rapid identification, and eliminating material consumption and waste. Requiring only a matching spectral signal, NIR is a non-destructive test which removes the drawbacks of other systems. Our systems have been in use on products produced at PMRS for more than 10 years. The combination of NIR testing of raw materials and uniformity systems allow PMRS to perform pharmaceutical compounding at lower costs and with an exceptional level of quality.

Ready To Start Your Project With PMRS?

We understand the complexity of your project and the challenges it may entail. Through our extensive experience and knowledge, we will identify and anticipate problems before they occur. We will work with you to develop and manufacture your product, utilizing the best and latest technologies along the way. You can rest assured PMRS will consistently produce your product to the highest level standards every time.